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APP antibody (AA 18-38)
APP
Reactivity: Human, Mouse
WB
Host: Mouse
Monoclonal
3-00E-009
unconjugated
Product Details anti-APP Antibody
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Target
See all APP Antibodies
APP
(Amyloid beta (A4) Precursor Protein (APP))
Binding Specificity
All epitopes for APP antibodies
AA 18-38
Reactivity
All reactivities for APP antibodies
Human, Mouse
Host
All hosts for APP antibodies
Mouse
Clonality
All clonalities for APP antibodies
Monoclonal
Conjugate
All conjugates for APP antibodies
This APP antibody is un-conjugated
Application
All applications for APP antibodies
Western Blotting (WB)
Sequence
LEVPTDGNAG LLAEPQIAMF C
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse
Purification
Protein A agarose
Immunogen
Synthetic peptide corresponding to APP695 (18-38 aa)
Clone
3-00E-009
Isotype
IgG1
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Discover our top product APP Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore with 100 μL of distilled water.
Buffer
PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Target Details for APP
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Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Alternative Name
Amyloid beta A4 Protein / APP (APP Products )
Synonyms
AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN-II antibody, PN2 antibody, aaa antibody, abeta antibody, abpp antibody, ad1 antibody, appi antibody, ctfgamma antibody, cvap antibody, pn2 antibody, APP antibody, APP-like antibody, APPL antibody, Abeta antibody, BcDNA:GH04413 antibody, CG7727 antibody, Dmel\\CG7727 antibody, EG:65F1.5 antibody, appl antibody, Abpp antibody, Adap antibody, Ag antibody, Cvap antibody, E030013M08Rik antibody, betaApp antibody, app antibody, wu:fj34d10 antibody, wu:fk65e12 antibody, zgc:85740 antibody, amyloid beta precursor protein antibody, amyloid beta (A4) precursor protein antibody, beta amyloid protein precursor-like antibody, amyloid beta (A4) precursor protein a antibody, amyloid beta precursor protein L homeolog antibody, APP antibody, app antibody, Appl antibody, App antibody, appa antibody, app.L antibody
Background
Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID
351
NCBI Accession
NP_000475
UniProt
P05067
Pathways
Caspase Cascade in Apoptosis , EGFR Signaling Pathway , Transition Metal Ion Homeostasis , Skeletal Muscle Fiber Development , Toll-Like Receptors Cascades , Feeding Behaviour
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