ALKBH1 antibody (N-Term)

Catalog No. ABIN1449917

Product Details anti-ALKBH1 Antibody

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PGFIFIPNPF LPGYQWHWVK QCLKLYSQKP NVCNLDKHMS KEETQDLWEQ

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Dog, MouseSpecies reactivity (tested):Human

Purification: Immunoaffinity column

Immunogen: Synthetic peptide corresponding to a N-terminal region of human ALKBH1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for ALKBH1

Target: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Alternative Name: ALKBH1 (ALKBH1 Products)

Synonyms: Alkbh antibody, ABH antibody, ABH1 antibody, ALKBH antibody, alkB antibody, hABH antibody, 2700073G19Rik antibody, Abh antibody, alkB homolog 1, histone H2A dioxygenase antibody, Alkbh1 antibody, ALKBH1 antibody

Background: ALKBH1 is a dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. This requires molecular oxygen, alpha-ketoglutarate and iron. ALKBH1 may have a role in placental trophoblast lineage differentiation, has DNA lyase activity and introduces double-stranded breaks at abasic sites. It cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.Synonyms: ABH, ALKBH, Alkylated DNA repair protein alkB homolog 1

Molecular Weight: ALX1: 37 kDa

Gene ID: 8846

NCBI Accession: NP_006011

Pathways: DNA Damage Repair