This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-326 amino acids from the C-terminal region of human SPO11.
CT35 antibody, SPATA43 antibody, TOPVIA antibody, zgc:77876 antibody, AI449549 antibody, Meiotic recombination protein spo-11 antibody, SPO11, initiator of meiotic double stranded breaks antibody, SPO11 meiotic protein covalently bound to DSB antibody, spo-11 antibody, SPO11 antibody, Spo11 antibody, spo11 antibody
Background
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.