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TNNT3 antibody (C-Term)

TNNT3 Reactivity: Human WB Host: Rabbit Polyclonal RB36783 unconjugated
Catalog No. ABIN1537681
  • Target See all TNNT3 Antibodies
    TNNT3 (Fast Skeletal Troponin T (TNNT3))
    Binding Specificity
    • 11
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 217-245, C-Term
    Reactivity
    • 40
    • 10
    • 9
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 28
    • 10
    • 2
    Rabbit
    Clonality
    • 32
    • 8
    Polyclonal
    Conjugate
    • 22
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNNT3 antibody is un-conjugated
    Application
    • 31
    • 17
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This TNNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the C-terminal region of human TNNT3.
    Clone
    RB36783
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TNNT3 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    TNNT3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    TNNT3 (Fast Skeletal Troponin T (TNNT3))
    Alternative Name
    TNNT3 (TNNT3 Products)
    Synonyms
    fTnT antibody, tnnt3a antibody, TNTF antibody, TnTf antibody, Tnt antibody, Tnnt3 antibody, troponin T3, fast skeletal type antibody, troponin T3, skeletal, fast antibody, troponin T3, fast skeletal type S homeolog antibody, troponin T type 3 (skeletal, fast) antibody, troponin T1, slow skeletal type antibody, TNNT3 antibody, Tnnt3 antibody, tnnt3.S antibody, TNNT1 antibody
    Background
    The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).
    Molecular Weight
    31825
    Gene ID
    7140
    NCBI Accession
    NP_001036245, NP_001036246, NP_001036247, NP_006748
    UniProt
    P45378
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