Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

TNNT3 Products

(Fast Skeletal Troponin T (TNNT3))

Categories

The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein\; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured TNNT3 Categories

TNNT3 Antibodies

High quality antibodies with extensive validation data.

TNNT3 ELISA Kits

Reliable ELISA kits for a wide range of species.

TNNT3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TNNT3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (2)
Cat. No. ABIN563217
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, ICC, IF
Validations
  • (2)
Cat. No. ABIN6257189
Quantity 100 μL
Datasheet Datasheet
Reactivity Chicken, Human, Quail
Application WB, ELISA, IHC, IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN462336
Quantity 50 μg
Datasheet Datasheet

Recommended TNNT3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6963595
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970896
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970897
Quantity 96 tests
Datasheet Datasheet

Recommended TNNT3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323292
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7401554
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2720887
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our TNNT3 products

Zhang, Pereyra, Wang, Birbrair, Reisz, Files, Purcell, Feng, Messi, Feng, Chalovich, Jin, Furdui, Delbono: "Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice." in: Aging cell, Vol. 15, Issue 3, pp. 488-98, (2016) (PubMed).

Hajje, Saliba, Itani, Moubarak, Aftimos, Farès: "Hypothyroidism and its rapid correction alter cardiac remodeling." in: PLoS ONE, Vol. 9, Issue 10, pp. e109753, (2014) (PubMed).

Zhang, Birbrair, Wang, Taylor, Messi, Delbono: "Troponin T nuclear localization and its role in aging skeletal muscle." in: Age (Dordrecht, Netherlands), Vol. 35, Issue 2, pp. 353-70, (2013) (PubMed).

Zhang, Birbrair, Delbono: "Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis." in: Cytoskeleton (Hoboken, N.J.), Vol. 70, Issue 3, pp. 134-47, (2013) (PubMed).

Chaze, Meunier, Chambon, Jurie, Picard: "Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle." in: Animal : an international journal of animal bioscience, Vol. 3, Issue 7, pp. 980-1000, (2012) (PubMed).

Zhao, Jiang, Han, Bian, Li, Huang, Kong, Li: "A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus." in: European journal of medical genetics, Vol. 54, Issue 3, pp. 351-3, (2011) (PubMed).

Synonyms and alternative names related to TNNT3

troponin T3, fast skeletal type (TNNT3), troponin T3, skeletal, fast (Tnnt3), troponin T3, fast skeletal type S homeolog (tnnt3.S), troponin T3, fast skeletal type (Tnnt3), troponin T type 3 (skeletal, fast) (TNNT3), troponin T1, slow skeletal type (TNNT1), fTnT, Tnnt3, tnnt3a, Tnt, TNTF, TnTf

Protein level used designations for TNNT3

  • troponin T variant TnTx7-e16
  • troponin T, fast skeletal muscle isoforms
  • troponin T3, skeletal, fast
  • fast skeletal muscle troponin T
  • fast skeletal muscle troponin T3
  • skeletal muscle fast-twitch TnT
  • tnTf
  • troponin T, fast skeletal muscle
  • beta TnTF
  • beta-TnTF
  • fTnT
  • troponin-T3, skeletal, fast
  • troponin T fast skeletal muscle type
  • fast skeletal troponin T beta-1 isoform
  • skeletal troponin T alpha-1 isoform
  • Fast skeletal muscle troponin T
  • Troponin T, fast skeletal muscle
  • fetal troponin T 1
  • fetal troponin T 2
  • troponin T 2f
  • troponin T 2fa
  • troponin T 4f
  • troponin T1f
  • troponin T type 1 (skeletal, slow)
  • troponin T, slow skeletal muscle
You are here:
Support