EFCAB4B antibody (N-Term)

Catalog No. ABIN2849476

Product Details anti-EFCAB4B Antibody

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Binding Specificity: AA 48-74, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFCAB4B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.

Clone: RB38227

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: EFCAB4B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for EFCAB4B

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Alternative Name: EFCAB4B (EFCAB4B Products)

Synonyms: CRACR2A antibody, Gm1073 antibody, Gm462 antibody, calcium release activated channel regulator 2A antibody, CRACR2A antibody, Cracr2a antibody

Background: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Molecular Weight: 45592

Gene ID: 84766

NCBI Accession: NP_001138430, NP_116069

UniProt: Q9BSW2