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EFCAB4B antibody (N-Term)

EFCAB4B Reactivity: Human WB Host: Rabbit Polyclonal RB38227 unconjugated
Catalog No. ABIN1539404
  • Target See all EFCAB4B Antibodies
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Binding Specificity
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 48-74, N-Term
    Reactivity
    • 23
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 21
    • 2
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This EFCAB4B antibody is un-conjugated
    Application
    • 23
    • 13
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.
    Clone
    RB38227
    Isotype
    Ig Fraction
    Top Product
    Discover our top product EFCAB4B Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    EFCAB4B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Alternative Name
    EFCAB4B (EFCAB4B Products)
    Synonyms
    CRACR2A antibody, Gm1073 antibody, Gm462 antibody, calcium release activated channel regulator 2A antibody, CRACR2A antibody, Cracr2a antibody
    Background
    Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
    Molecular Weight
    45592
    Gene ID
    84766
    NCBI Accession
    NP_001138430, NP_116069
    UniProt
    Q9BSW2
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