CYP1B1 antibody (AA 441-543) (Alexa Fluor 350)
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- Target See all CYP1B1 Antibodies
- CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))
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Binding Specificity
- AA 441-543
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CYP1B1 antibody is conjugated to Alexa Fluor 350
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat,Dog,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human CYP1B1
- Isotype
- IgG
- Top Product
- Discover our top product CYP1B1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))
- Alternative Name
- CYP1B1 (CYP1B1 Products)
- Synonyms
- CP1B antibody, CYPIB1 antibody, GLC3A antibody, P4501B1 antibody, P4501b1 antibody, CYP1B1 antibody, CYP1B antibody, zgc:136223 antibody, cytochrome P450 family 1 subfamily B member 1 antibody, cytochrome P450, family 1, subfamily b, polypeptide 1 antibody, cytochrome P450, family 1, subfamily B, polypeptide 1 antibody, cytochrome P450 1B1 antibody, CYP1B1 antibody, Cyp1b1 antibody, cyp1b1 antibody, LOC100719054 antibody
- Background
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Synonyms: CP1B, GLC3A, CYPIB1, P4501B1, Cytochrome P450 1B1, CYP1B1
Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
- Gene ID
- 1545
- UniProt
- Q16678
- Pathways
- Steroid Hormone Biosynthesis
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