GM2A antibody (AA 131-193) (HRP)

Catalog No. ABIN1711029

Product Details anti-GM2A Antibody (HRP)

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Binding Specificity: AA 131-193

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GM2A antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GM2A/SAP3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GM2A

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Alternative Name: GM2A (GM2A Products)

Synonyms: GM2A antibody, fb96e04 antibody, fb96e10 antibody, wu:fb96e04 antibody, wu:fb96e10 antibody, zgc:110188 antibody, MGC84154 antibody, GM2-AP antibody, SAP-3 antibody, AA408702 antibody, AW215435 antibody, GM2 ganglioside activator antibody, GM2 ganglioside activator L homeolog antibody, GM2 ganglioside activator protein antibody, Gm2a antibody, GM2A antibody, gm2a antibody, gm2a.L antibody

Background:

Synonyms: SAP-3, GM2-AP, Ganglioside GM2 activator, Cerebroside sulfate activator protein, Sphingolipid activator protein 3, GM2A

Background: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 Molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

Gene ID: 2760

UniProt: P17900