BCL10 antibody (N-Term)

Catalog No. ABIN1732247

Product Details anti-BCL10 Antibody

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Binding Specificity: AA 5-19, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Specificity: Reacts with human Bcl-10.

Purification: Purified

Immunogen: Synthetic peptide corresponding to aa 5-19 (N-terminus ) of human Bcl-10

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC-P (10 μg/mL) WB(1 μg/mL) ICC(1 μg/mL)

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: Bcl-10 (BCL10 Products)

Synonyms: CARMEN antibody, CIPER antibody, CLAP antibody, c-E10 antibody, mE10 antibody, BCL10 antibody, AI132454 antibody, BCL-10 antibody, C81403 antibody, ME10 antibody, cE10 antibody, bcl10 antibody, B-cell CLL/lymphoma 10 antibody, B-cell lymphoma/leukemia 10-like antibody, B cell leukemia/lymphoma 10 antibody, B-cell lymphoma/leukemia 10 antibody, BCL10 antibody, Bcl10 antibody, bcl10 antibody, LOC100223183 antibody

Background: Overexpression of Bcl10 induces JNK, p38, and NF- B activation. Bcl10 interacts with caspase- 9, enhances pro-caspase-9 processing, and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphoma and in B and T cell lymphomas indicating that it may be commonly involved in the pathogenesis of human tumors. Bcl10 is expressed in many human and murine tissues and cell lines.

B-cell lymphoma/leukemia 10 B-cell CLL/lymphoma 10, Bcl-10 CARD-containing molecule enhancing NF-kappa-B CARD-like apoptotic protein, hCLAP CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER Cellular homolog of vCARMEN, cCARMEN Cellular-E10, c-E10 Mammalian CARD-containing adapter molecule E10, mE10 Gene name: BCL10, CARMEN, CIPER, CLAP, IMD37

Gene ID: 8915

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins