APOE antibody (AA 140-160)

Catalog No. ABIN1820139

Product Details anti-APOE Antibody

Target: APOE (Apolipoprotein E (APOE))

Binding Specificity: AA 140-160

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone 6-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor.

Purification: Protein G purified

Immunogen: Purified ApoHDL fraction.

Type of Immunogen: Purified protein

Clone: WUE-4

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1:100 - 1:1000), WB

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for APOE

Target: APOE (Apolipoprotein E (APOE))

Alternative Name: APOE / Apolipoprotein E (APOE Products)

Synonyms: ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody

Background: Name/Gene ID: APOE

Synonyms: APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG

Gene ID: 348

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism