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MCAM antibody (AA 84-189)
MCAM
Reactivity: Human
FACS, IHC, WB, ELISA
Host: Mouse
Monoclonal
unconjugated
Product Details anti-MCAM Antibody
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Target
See all MCAM Antibodies
MCAM
(Melanoma Cell Adhesion Molecule (MCAM))
Binding Specificity
All epitopes for MCAM antibodies
AA 84-189
Reactivity
All reactivities for MCAM antibodies
Human
Host
All hosts for MCAM antibodies
Mouse
Clonality
All clonalities for MCAM antibodies
Monoclonal
Conjugate
All conjugates for MCAM antibodies
This MCAM antibody is un-conjugated
Application
All applications for MCAM antibodies
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB), ELISA
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. coli.
Isotype
IgG1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for MCAM
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Target
MCAM
(Melanoma Cell Adhesion Molecule (MCAM))
Alternative Name
MCAM (MCAM Products )
Synonyms
CD146 antibody, MUC18 antibody, Muc18 antibody, 1-gicerin antibody, AV025631 antibody, CD149 antibody, s-endo antibody, s-gicerin antibody, cd146 antibody, gicerin antibody, id:ibd3512 antibody, mcam antibody, MCAM antibody, melanoma cell adhesion molecule antibody, melanoma cell adhesion molecule b antibody, MCAM antibody, Mcam antibody, mcamb antibody
Background
The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread.Could be an adhesion molecule active in neural crest cells during embryonic development.Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Molecular Weight
71.6 kDa
Gene ID
4162
UniProt
P43121
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