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RAF1 antibody
RAF1
Reactivity: Human
WB, ELISA, IHC, FACS
Host: Mouse
Monoclonal
unconjugated
Product Details anti-RAF1 Antibody
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Target
See all RAF1 Antibodies
RAF1
(V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
Reactivity
All reactivities for RAF1 antibodies
Human
Host
All hosts for RAF1 antibodies
Mouse
Clonality
All clonalities for RAF1 antibodies
Monoclonal
Conjugate
All conjugates for RAF1 antibodies
This RAF1 antibody is un-conjugated
Application
All applications for RAF1 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human RAF1 expressed in E. coli.
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for RAF1
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Target
RAF1
(V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
Alternative Name
RAF1 (RAF1 Products )
Synonyms
CRAF antibody, NS5 antibody, Raf-1 antibody, c-Raf antibody, c-raf antibody, craf antibody, raf1 antibody, RAF1 antibody, 6430402F14Rik antibody, AA990557 antibody, BB129353 antibody, Craf1 antibody, D830050J10Rik antibody, v-Raf antibody, raf antibody, cRaf antibody, Raf-1 proto-oncogene, serine/threonine kinase antibody, Raf-1 proto-oncogene, serine/threonine kinase a antibody, v-raf-leukemia viral oncogene 1 antibody, Raf-1 proto-oncogene, serine/threonine kinase S homeolog antibody, RAF1 antibody, Raf1 antibody, raf1a antibody, raf1 antibody, raf1.S antibody
Background
This gene is the cellular homolog of viral raf gene (v-raf).The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly.Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2.Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Molecular Weight
73 kDa
Gene ID
5894
UniProt
P04049
Pathways
MAPK Signaling , RTK Signaling , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , cAMP Metabolic Process , Stem Cell Maintenance , Hepatitis C , Autophagy , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling , BCR Signaling
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