BAD antibody (pThr80)

Catalog No. ABIN1881100

This Rabbit Polyclonal antibody specifically detects BAD in DB. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for BAD antibody (pThr80) (ABIN1881100)

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAD antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB39409

Product Details anti-BAD Antibody

Binding Specificity: pThr80

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T80 of human BAD.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BAD antibody (ABIN1881100)

Galmiche, Ezzoukhry, François, Louandre, Sabbagh, Nguyen-Khac, Descamps, Trouillet, Godin, Regimbeau, Joly, Barbare, Duverlie, Mazière, Chatelain: "BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma." in: Molecular cancer research : MCR, Vol. 8, Issue 8, pp. 1116-25, (2010) (PubMed).

Yu, Sun, Shen, Gao, Fan, Sun: "Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity." in: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 107, (2010) (PubMed).

Target Details for BAD

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Alternative Name: BAD

Background: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq].

Molecular Weight: 18392

NCBI Accession: NP_004313, NP_116784

UniProt: Q92934

Pathways: MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events