HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (pTyr1005)

Details for Product anti-ERBB2 Antibody No. ABIN1881312, Supplier: Log in to see
Antigen
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Alternatives
anti-Human HER2 antibody for Western Blotting
Epitope
pTyr1005
128
86
70
68
59
49
48
35
30
30
25
22
21
16
15
15
13
13
12
12
11
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11
11
11
11
11
11
11
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11
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10
8
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5
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4
4
4
4
4
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3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1302
400
297
28
21
8
4
4
4
4
3
3
3
2
1
1
1
Host
Rabbit
786
587
29
14
11
3
3
Clonality (Clone)
Polyclonal ()
Conjugate
This HER2 antibody is un-conjugated
59
45
44
42
41
27
20
20
13
13
13
13
11
11
8
8
8
8
8
7
7
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6
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6
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6
6
6
6
6
6
3
2
2
1
Application
Dot Blot (DB), Immunofluorescence (IF), Western Blotting (WB)
668
466
429
396
342
200
198
102
102
101
87
47
24
21
18
11
6
4
3
3
2
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1005 of human ERBB2.
Clone RB41781
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Plasmids, Primers & others Plasmids, Primers & others HER2 products on genomics-online (e.g. as negative or positive controls)
Alternative Name ERBB2 (ERBB2 Antibody Abstract)
Background This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Synonyms: ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD_antigen=CD340, Flags: Precursor
NCBI Accession NP_001005862, NP_004439
UniProt P04626
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
Application Notes WB: 1:1000,IF: 1:100,DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pTyr1005) antibody (ABIN1881312) Dot blot analysis of ERBB2 Antibody (Phospho Y1005) Phospho-specific Pab (ABIN1881312...
Immunofluorescence (IF) image for anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pTyr1005) antibody (ABIN1881312) Dot blot analysis of ERBB2 Antibody (Phospho Y1005) Phospho-specific Pab (ABIN1881312...
Western Blotting (WB) image for anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pTyr1005) antibody (ABIN1881312) Dot blot analysis of ERBB2 Antibody (Phospho Y1005) Phospho-specific Pab (ABIN1881312...
Product cited in: Lacroix, Leclercq: "Relevance of breast cancer cell lines as models for breast tumours: an update." in: Breast cancer research and treatment, Vol. 83, Issue 3, pp. 249-89, 2004 (PubMed).

Levenson, Jordan: "MCF-7: the first hormone-responsive breast cancer cell line." in: Cancer research, Vol. 57, Issue 15, pp. 3071-8, 1997 (PubMed).

Soule, Vazguez, Long, Albert, Brennan: "A human cell line from a pleural effusion derived from a breast carcinoma." in: Journal of the National Cancer Institute, Vol. 51, Issue 5, pp. 1409-16, 1974 (PubMed).

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