TSC1 antibody (pTyr304)

Catalog No. ABIN1881933

Product Details anti-TSC1 Antibody

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Binding Specificity: pTyr304

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y304 of human TSC1.

Clone: RB42253

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TSC1 antibody (ABIN1881933)

Mehta, Vazquez, Kulkarni, Kerrigan, Atwal, Metsugi, Toppmeyer, Levine, Hirshfield: "Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes." in: Breast cancer research and treatment, Vol. 125, Issue 3, pp. 861-8, (2011) (PubMed).

Hoogeveen-Westerveld, Exalto, Maat-Kievit, van den Ouweland, Halley, Nellist: "Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction." in: Biochimica et biophysica acta, Vol. 1802, Issue 9, pp. 774-81, (2010) (PubMed).

Mieulet, Lamb: "Tuberous sclerosis complex: linking cancer to metabolism." in: Trends in molecular medicine, Vol. 16, Issue 7, pp. 329-35, (2010) (PubMed).

Guo, Ying, Zhang, Yuan, Qian, Wang, Yang, He: "Tandem affinity purification and identification of the human TSC1 protein complex." in: Acta biochimica et biophysica Sinica, Vol. 42, Issue 4, pp. 266-73, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1 (TSC1 Products)

Synonyms: LAM antibody, TSC antibody, hamartin antibody, mKIAA0243 antibody, tsc1 antibody, wu:fc38b04 antibody, fa99f04 antibody, wu:fa99f04 antibody, zgc:63657 antibody, TSC complex subunit 1 antibody, tuberous sclerosis 1 antibody, TSC complex subunit 1b antibody, TSC complex subunit 1a antibody, TSC1 antibody, Tsc1 antibody, tsc1b antibody, tsc1 antibody, tsc1a antibody

Background: This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

Molecular Weight: 129767

NCBI Accession: NP_000359, NP_001155898, NP_001155899

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation