Transforming growth factor (TGF)-beta is a multifunctional cytokine that modulates several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production.Three TGF-beta forms are encoded by separate genes: TGFB1 (MIM 190180), TGFB2 (MIM 190220), and TGFB3 (MIM 190230).The diverse effects of TGF-beta are mediated by the TGF-beta receptors and cell surface-binding proteins.Three TGF-beta receptors exist: type I (TGFBR1, MIM 190181), type II (TFGBR2, MIM 190182), and type III (TGFBR3).TGFBR3 is a glycoprotein that binds TGFB and exists in both a membrane-bound and a soluble form (Johnson et al., 1995 [PubMed 8530052]).[supplied by OMIM]