TYW1 antibody (C-Term)

Catalog No. ABIN1887290

Product Details anti-TYW1 Antibody

Target: TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYW1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): TYW1 antibody is predicted to not cross-react with other TYW protein family members. At least three isoforms of TYW1 are known to exist, this antibody will only detect the two larger isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human TYW1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TYW1

Target: TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))

Alternative Name: TYW1 (TYW1 Products)

Synonyms: RSAFD1 antibody, TYW1A antibody, YPL207W antibody, RGD1310420 antibody, Rsafd1 antibody, AW125391 antibody, im:6898509 antibody, wu:fb74d01 antibody, zgc:153368 antibody, tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) antibody, S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase antibody, tRNA-yW synthesizing protein 1 homolog S homeolog antibody, tRNA-yW synthesizing protein 1 homolog antibody, TYW1 antibody, LOC100354908 antibody, tyw1.S antibody, Tyw1 antibody, tyw1 antibody

Background: TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway.Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome.TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7.Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions
Synonyms: TYW1, Radical S-adenosyl methionine and flavodoxin domain-containing protein 1, RSAFD1, tRNA wybutosine-synthesizing protein 1 homolog, TYW1A, YPL207W

NCBI Accession: NP_060734