Anosmin antibody (Center)

Catalog No. ABIN1887739

Product Details anti-Anosmin Antibody

Target: Anosmin (ANOS1)

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Anosmin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: Anosmin antibody was raised against an 18 amino acid peptide near the center of human Anosmin.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Anosmin

Target: Anosmin (ANOS1)

Abstract: ANOS1 Products

Synonyms: ADMLX antibody, HH1 antibody, HHA antibody, KAL antibody, KALIG-1 antibody, KMS antibody, WFDC19 antibody, anosmin 1 antibody, ANOS1 antibody

Background: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron.Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1.It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
Synonyms: Anosmin, Anosmin-1, KALIG-1, KAL1, HHA, KMS,

NCBI Accession: NP_000207