Cyclin O antibody (N-Term)

Catalog No. ABIN1887870

Product Details anti-Cyclin O Antibody

Target: Cyclin O (CCNO)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin O antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the amino terminus of human UNG2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Cyclin O

Target: Cyclin O (CCNO)

Alternative Name: Cyclin O (CCNO Products)

Synonyms: RGD1565217 antibody, ccnu antibody, udg2 antibody, ung2 antibody, CCNU antibody, MGC131111 antibody, C86987 antibody, Ccnu antibody, E130318K11 antibody, Ung2 antibody, UDG2 antibody, cyclin O antibody, cyclin O L homeolog antibody, Ccno antibody, ccno antibody, CCNO antibody, ccno.L antibody

Background: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing.UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination.UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome.As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.This UNG2 antibody will not cross-react with UNG1.
Synonyms: Uracil-DNA glycosylase 2, UDG2

NCBI Accession: NP_066970