INSM1 antibody (N-Term)

Catalog No. ABIN1888097

Product Details anti-INSM1 Antibody

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide from near the amino terminus of human IA-1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: IA-1 (INSM1 Products)

Synonyms: IA-1 antibody, IA1 antibody, INSM-1 antibody, Insm1 antibody, fc13a09 antibody, wu:fc13a09 antibody, zINSM-1 antibody, zgc:63866 antibody, INSM1 antibody, ia-1 antibody, zgc:77257 antibody, INSM transcriptional repressor 1 antibody, insulinoma-associated 1 antibody, insulinoma-associated 1b antibody, insulinoma associated 1 antibody, insulinoma associated 1 L homeolog antibody, insulinoma-associated 1a antibody, INSM1 antibody, Insm1 antibody, insm1b antibody, insm1 antibody, insm1.L antibody, insm1a antibody

Background: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system.Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb.It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation.IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Synonyms: Insulinoma-associated 1, INSM1, IA1

NCBI Accession: NP_002187