This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, (1989) (PubMed).
Peltz, Grundy, Lebo, Yssel, Barsh, Moore: "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 3, pp. 1013-7, (1989) (PubMed).
Scallon, Scigliano, Freedman, Miedel, Pan, Unkeless, Kochan: "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 13, pp. 5079-83, (1989) (PubMed).
Simmons, Seed: "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein." in: Nature, Vol. 333, Issue 6173, pp. 568-70, (1988) (PubMed).
Target
FCGR3B
(Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B))
CD16 antibody, CD16b antibody, FCG3 antibody, FCGR3 antibody, FCR-10 antibody, FCRIII antibody, FCRIIIb antibody, FcRIII antibody, Fc fragment of IgG receptor IIIb antibody, Fc receptor, IgG, low affinity III antibody, Fc fragment of IgG receptor IIIa antibody, Fc-gamma RIII antibody, FCGR3B antibody, Fcgr3 antibody, FCGR3A antibody, FCGR3 antibody
Background
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.