Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (AA 162-195), (Center) antibody

Details for Product No. ABIN1944758, Supplier: Log in to see
Antigen
  • CK2A1
  • CKII
  • CSNK2A3
  • CK2A
  • Ck2a
  • BmCK2a
  • wu:fi38e04
  • wu:fi38h03
  • CSNK2A1
  • csnk2a1
  • CK-II
  • CK2
  • Ckiialpha
  • Csnk2a1-rs4
  • ck2a1
  • casein kinase 2 alpha 1
  • casein kinase 2 alpha subunit
  • casein kinase 2, alpha 1 polypeptide
  • CK2 protein kinase alpha 2
  • casein kinase II alpha subunit
  • Casein kinase II alpha subunit
  • casein kinase 2, alpha 1 polypeptide S homeolog
  • CSNK2A1
  • ck2a
  • Ck2a
  • csnk2a1
  • cka2
  • Ckiialpha
  • CK2A1
  • Csnk2a1
  • csnk2a1.S
Epitope
AA 162-195, Center
15
14
11
7
7
6
5
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
144
78
69
8
7
7
6
5
5
3
3
3
2
2
2
2
1
1
Host
Rabbit
126
21
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
5
5
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
120
64
54
22
14
13
11
4
3
2
2
1
1
Options
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Immunogen This CSNK2A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 AA from the Central region of human CSNK2A1.
Clone RB48212
Isotype Ig
Predicted Reactivity Mouse (Murine),Rat (Meriones),Cow (Bovine),Chicken,Fruit Fly (Drosophila sp.),Rabbit,Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Antigen Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1)
Alternative Name CSNK2A1 (CSNK2A1 Antibody Abstract)
Background Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation.
Synonyms: Casein kinase II subunit alpha, CK II alpha, CSNK2A1, CK2A1
Molecular Weight 45144 Da
Gene ID 1457
UniProt P68400
Application Notes WB - 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (AA 162-195), (Center) antibody (ABIN1944758) anti-Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (AA 162-195), (Center) antibody
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Product cited in: Devilat, Carvallo: "Structure and sequence of an intronless gene for human casein kinase II-alpha subunit." in: FEBS letters, Vol. 316, Issue 2, pp. 114-8, 1993 (PubMed).

Lozeman, Litchfield, Piening, Takio, Walsh, Krebs: "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II." in: Biochemistry, Vol. 29, Issue 36, pp. 8436-47, 1991 (PubMed).

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