CD74
Reactivity: Human
WB, IHC
Host: Rabbit
Monoclonal
unconjugated
Application Notes
WB: 1:1000. FC: 1:25
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Kudo, Chao, Narni, Saunders: "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens." in: Nucleic acids research, Vol. 13, Issue 24, pp. 8827-41, (1986) (PubMed).
OSullivan, Larhammar, Wilson, Peterson, Quaranta: "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 12, pp. 4484-8, (1986) (PubMed).
Claesson, Larhammar, Rask, Peterson: "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 24, pp. 7395-9, (1984) (PubMed).
Strubin, Mach, Long: "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity." in: The EMBO journal, Vol. 3, Issue 4, pp. 869-72, (1984) (PubMed).
DHLAG antibody, HLADG antibody, II antibody, Ia-GAMMA antibody, CLIP antibody, Ii antibody, INVG34 antibody, Iclp-1 antibody, iclp1 antibody, wu:fb11f09 antibody, wu:fb12a01 antibody, wu:fb13d06 antibody, wu:fk94e07 antibody, Iclp-2 antibody, cd74 antibody, iclp2 antibody, zgc:123161 antibody, CD74 molecule antibody, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody, CD74 molecule, major histocompatibility complex, class II invariant chain a antibody, CD74 molecule, major histocompatibility complex, class II invariant chain b antibody, CD74 antibody, Cd74 antibody, cd74a antibody, cd74b antibody
Background
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.