DIABLO antibody (C-Term)

Catalog No. ABIN205899

Product Details anti-DIABLO Antibody

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Binding Specificity: AA 225-239, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIABLO antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes the C-terminal region of human Smac/DIABLO. Inhibitors of apoptosis proteins (IAP's) block cell death by caspase inhibition. X-linked inhibitor of apoptosis (XIAP) is a member of the IAP family. Smac/DIABLO is expressed in a variety of tissues and has been identified as a negative regulator of XIAP.

Purification: Purified

Immunogen: Synthetic peptide corresponding to amino acids 225-239 of human Smac/DIABLO ( C-TERMINAL ).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IHC, IHC-P (5 μg/mL), WB (1 μg/mL)

Usage: Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Alternative Name: DIABLO / SMAC (DIABLO Products)

Synonyms: smac antibody, smac3 antibody, diablo-s antibody, 0610041G12Rik antibody, 1700006L01Rik antibody, AU040403 antibody, Smac antibody, DFNA64 antibody, SMAC antibody, DBO antibody, XSmac antibody, diablo, IAP-binding mitochondrial protein antibody, diablo IAP-binding mitochondrial protein antibody, diablo, IAP-binding mitochondrial protein L homeolog antibody, diablo antibody, Diablo antibody, DIABLO antibody, diablo.L antibody

Background: Name/Gene ID: DIABLO
Family: Apoptosis

Synonyms: DIABLO, DFNA64, DIABLO-S, Diablo homolog, mitochondrial, SMAC3, Mitochondrial Smac protein, SMAC

Gene ID: 56616

UniProt: Q9NR28

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity