VIPR1 antibody (AA 151-250) (Alexa Fluor 350)
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- Target See all VIPR1 Antibodies
- VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))
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Binding Specificity
- AA 151-250
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VIPR1 antibody is conjugated to Alexa Fluor 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human GPCR RDC1
- Isotype
- IgG
- Top Product
- Discover our top product VIPR1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))
- Alternative Name
- Rdc1 (VIPR1 Products)
- Synonyms
- HVR1 antibody, II antibody, PACAP-R-2 antibody, PACAP-R2 antibody, RDC1 antibody, V1RG antibody, VAPC1 antibody, VIP-R-1 antibody, VIPR antibody, VIRG antibody, VPAC1 antibody, VPAC1R antibody, VPCAP1R antibody, CVIPR antibody, AV071699 antibody, VIP-R1 antibody, RATVASREC antibody, VASREC antibody, VIPR1 antibody, LOC100226500 antibody, vipr1 antibody, hvr1 antibody, rdc1 antibody, v1rg antibody, vipr antibody, virg antibody, vapc1 antibody, vpac1 antibody, vpcap1 antibody, vpac1-r antibody, VIP-R antibody, vasoactive intestinal peptide receptor 1 antibody, vasoactive intestinal peptide receptor 1b antibody, vasoactive intestinal peptide receptor 1 S homeolog antibody, vasoactive intestinal polypeptide receptor antibody, VIPR1 antibody, Vipr1 antibody, vipr1b antibody, vipr1 antibody, vipr1.S antibody, LOC100303683 antibody
- Background
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Synonyms: C-X-C chemokine receptor type 7, Chemokine orphan receptor 1, CMKOR1, CXC-R7, CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1, CXCR7_HUMAN, ACKR3
Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates
- Gene ID
- 57007
- UniProt
- P25106
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