C3AR1 antibody

Catalog No. ABIN2192050

Product Details anti-C3AR1 Antibody

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C3AR1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Sterility: 0.2 μm filtered

Clone: 17 (hC3aRZ8)

Application Details

Application Notes: is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for C3AR1

Target: C3AR1 (Complement Component 3a Receptor 1 (C3AR1))

Abstract: C3AR1 Products

Synonyms: C3AR antibody, C3a-R antibody, c3ar1 antibody, AZ3B antibody, HNFAG09 antibody, C3a anaphylatoxin chemotactic receptor antibody, complement C3a receptor 1 antibody, complement component 3a receptor 1 antibody, c3ar1 antibody, C3AR1 antibody, C3ar1 antibody

Background: The monoclonal antibody 17 reacts with the human receptor for C3a. The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.

Pathways: Complement System