Aconitase 1 antibody
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- Target See all Aconitase 1 (ACO1) Antibodies
- Aconitase 1 (ACO1)
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Aconitase 1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Affinity purification
- Immunogen
- Synthetic peptide of human ACO1
- Isotype
- IgG
- Top Product
- Discover our top product ACO1 Primary Antibody
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- Application Notes
- WB 1:1000-1:5000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- Preservative
- Sodium azide
- Handling Advice
- Avoid freeze / thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Aconitase 1 (ACO1)
- Alternative Name
- ACO1 (ACO1 Products)
- Synonyms
- ACONS antibody, IREB1 antibody, IREBP antibody, IREBP1 antibody, IRP1 antibody, Acon1 antibody, Ratireb antibody, ratireb antibody, Aco1 antibody, AI256519 antibody, Aco-1 antibody, Irebp antibody, Irp1 antibody, aconitase 1 antibody, aconitase 1, soluble antibody, aconitase 1 L homeolog antibody, ACO1 antibody, Aco1 antibody, aco1.L antibody
- Background
- Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
- Molecular Weight
- Calculated MW: 98 kDa
- NCBI Accession
- NP_002188
- Pathways
- Transition Metal Ion Homeostasis
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