MMP2
Reactivity: Human, Rat, Mouse
IHC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
IHC 1:50-1:200
Restrictions
For Research Use only
Format
Liquid
Concentration
1.2 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Handling Advice
Avoid freeze / thaw cycles.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Bi, Liu, Ding, Wu, Dou, Zhang, Yuan, Liu, Xiong, Guo, Mao: "A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression." in: European journal of pharmacology, Vol. 796, pp. 175-189, (2017) (PubMed).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.