PRNP antibody
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- Target See all PRNP Antibodies
- PRNP (Prion Protein (PRNP))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PRNP antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity (Details)
- Does not react with mouse Prion. Not tested with other species
- Purification
- Purified
- Sterility
- Sterile filtered
- Immunogen
- Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13.
- Clone
- 7A1
- Isotype
- IgG
- Top Product
- Discover our top product PRNP Primary Antibody
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- Application Notes
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1) Western blotting: ~0. 5 g/mL
2) ELISA
Other applications have not been tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol
- Preservative
- Azide free
- Storage
- -20 °C
- Storage Comment
- Upon arrival centrifuge briefly, aliquot and store at -20 C
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GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity." in: International journal of molecular medicine, Vol. 21, Issue 2, pp. 217-22, (2008) (PubMed).
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GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity." in: International journal of molecular medicine, Vol. 21, Issue 2, pp. 217-22, (2008) (PubMed).
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- Target
- PRNP (Prion Protein (PRNP))
- Alternative Name
- Prion Protein (PRNP Products)
- Synonyms
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ASCR antibody, AltPrP antibody, CD230 antibody, CJD antibody, GSS antibody, KURU antibody, PRIP antibody, PrP antibody, PrP27-30 antibody, PrP33-35C antibody, PrPc antibody, p27-30 antibody, Prn antibody, Prn-p antibody, prp antibody, cjd antibody, prion antibody, prp(c) antibody, MGC84114 antibody, PRP antibody, PRPC antibody, Prp antibody, SIP antibody, PRNP antibody, AA960666 antibody, AI325101 antibody, PrP
antibody, PrPC antibody, PrPSc antibody, Prn-i antibody, Sinc antibody, prP27-30 antibody, prP33-35C antibody, PrP-1 antibody, PrP1 antibody, prnprs1 antibody, stPrP-1 antibody, zgc:123004 antibody, prion protein antibody, prion protein S homeolog antibody, prion protein b antibody, PRNP antibody, Prnp antibody, prnp.S antibody, prnpb antibody - Background
- Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, which are responsible for appearance of multiple bands in SDS-PAGE.
- UniProt
- P04156
- Pathways
- Transition Metal Ion Homeostasis, Activated T Cell Proliferation
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