NR1D2 antibody
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- Target See all NR1D2 Antibodies
- NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
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Reactivity
- Human, Rat, Mouse, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR1D2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR1D2.
- Top Product
- Discover our top product NR1D2 Primary Antibody
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- Application Notes
- NR1D2 antibody can be used for detection of NR1D2 by ELISA at 1:62500. NR1D2 antibody can be used for detection of NR1D2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handling Advice
- As with any antibody avoid repeat freeze-thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store NR1D2 antibody at -20 °C.
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- Target
- NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
- Alternative Name
- NR1D2 (NR1D2 Products)
- Synonyms
- BD73 antibody, EAR-1R antibody, RVR antibody, HZF-2 antibody, Rev-erb antibody, REV-ERBB antibody, NR1D2 antibody, rvr antibody, bd73 antibody, hzf2 antibody, ear-1r antibody, hs.37288 antibody, NR1D2-A antibody, Reverbbeta-A antibody, reverbb1 antibody, reverbb antibody, reverbb2 antibody, zgc:92019 antibody, nuclear receptor subfamily 1 group D member 2 antibody, nuclear receptor subfamily 1, group D, member 2 antibody, nuclear receptor subfamily 1, group D, member 2a antibody, nuclear receptor subfamily 1, group D, member 2b antibody, NR1D2 antibody, Nr1d2 antibody, nr1d2 antibody, nr1d2a antibody, nr1d2b antibody
- Background
- NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
- Molecular Weight
- 65 kDa
- Gene ID
- 9975
- NCBI Accession
- NP_005117
- UniProt
- Q14995
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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