MXI1 antibody
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- Target See all MXI1 Antibodies
- MXI1 (MAX Interactor 1 (MXI1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MXI1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MXI1.
- Top Product
- Discover our top product MXI1 Primary Antibody
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- Application Notes
- MXI1 antibody can be used for detection of MXI1 by ELISA at 1:62500. MXI1 antibody can be used for detection of MXI1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handling Advice
- As with any antibody avoid repeat freeze-thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store MXI1 antibody at -20 °C.
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- Target
- MXI1 (MAX Interactor 1 (MXI1))
- Alternative Name
- MXI1 (MXI1 Products)
- Synonyms
- mxi antibody, mad2 antibody, mxd2 antibody, xmxi1 antibody, MGC89544 antibody, MXI1 antibody, etID309773.22 antibody, fb16b12 antibody, fb55f03 antibody, wu:fb16b12 antibody, wu:fb55f03 antibody, wu:fd06a08 antibody, wu:fz74f10 antibody, ENSMUSG00000067085 antibody, Gm10197 antibody, Mad2 antibody, bHLHc11 antibody, MXI-WR antibody, MAD2 antibody, MXD2 antibody, MXI antibody, MAX interactor 1, dimerization protein antibody, max interactor 1, dimerization protein antibody, MAX interactor 1, dimerization protein L homeolog antibody, mxi1 antibody, MXI1 antibody, Mxi1 antibody, mxi1.L antibody
- Background
- Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
- Molecular Weight
- 33 kDa
- Gene ID
- 4601
- NCBI Accession
- NP_569157
- Pathways
- Maintenance of Protein Location
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