LMAN1 antibody (AA 270-470)

Catalog No. ABIN2468020

Product Details anti-LMAN1 Antibody

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Binding Specificity: AA 270-470

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This LMAN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Application Details

Application Notes: ERGIC-53 protein antibody can be used for the detection of ERGIC-53 protein by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: LMAN1 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for LMAN1

Target: LMAN1 (Lectin, Mannose-Binding, 1 (LMAN1))

Alternative Name: LMAN1 (LMAN1 Products)

Synonyms: ERGIC-53 antibody, ERGIC53 antibody, F5F8D antibody, FMFD1 antibody, MCFD1 antibody, MR60 antibody, gp58 antibody, 2610020P13Rik antibody, AI326273 antibody, AU043785 antibody, C730041J05 antibody, P58 antibody, p58 antibody, LMAN1 antibody, cpx-iii antibody, cpxiii antibody, lman1 antibody, wu:fc54c09 antibody, wu:fi36e01 antibody, Xp58 antibody, lman1-a antibody, lectin, mannose binding 1 antibody, lectin, mannose-binding, 1 antibody, complexin 3 antibody, lectin, mannose binding 1 S homeolog antibody, LMAN1 antibody, Lman1 antibody, cplx3 antibody, lman1 antibody, lman1.S antibody

Background: FUNCTION: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

DISEASE: Defects in LMAN1 are a cause of factor V and factor VIII combined deficiency (F5F8D) [MIM:227300], also known as multiple coagulation factor deficiency I (MCFD1). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins. Affected patients present with a moderate bleeding tendency and have factor V and factor VIII levels in the range of 5-30 % of normal.

Molecular Weight: 57.5 kDa (calculated)

Gene ID: 3998

NCBI Accession: NP_005561

UniProt: P49257