Insulin Receptor antibody (Internal Region)

Catalog No. ABIN2469537

Product Details anti-Insulin Receptor Antibody

Target: Insulin Receptor (INSR)

Binding Specificity: Internal Region

Reactivity: Human, Monkey, Gorilla, Gibbon

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except JARID2 (69 % ).

Purification: Immunoaffinity Chromatography

Immunogen: Insulin Receptor antibody was raised against a peptide located near the internal domain of Insulin Receptor (Human).

Application Details

Application Notes: Insulin Receptor antibody can be used in ELISA starting at 1:10000, and immunohistochemistry starting at 1:200 - 1:400.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: Insulin Receptor antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: Insulin Receptor (INSR Products)

Synonyms: CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody

Background: INSR is an insulin receptor type protein kinase. Binding of insulin to INSR stimulates glucose uptake. Two insulin receptor mRNA transcripts resulting from alternative splicing of exon 11 in the receptor gene are expressed in a highly regulated tissue-specific fashion. Mutations in the INSR gene contribute to diseases, including of various forms of insulin resistance, insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus (NIDDM), Rabson-Mendenhall syndrome and Leprechaunism (Donohue Syndrome).

Gene ID: 3643

UniProt: P06213

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity