p21 antibody

Catalog No. ABIN2475991

This Mouse Monoclonal antibody specifically detects p21 in WB and IP. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for p21 antibody (ABIN2475991)

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This p21 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: WA-1

Product Details anti-p21 Antibody

Specificity: This antibody recognises the human cyclin-dependent kinase inhibitor p21/WAF1, which is an important cell cycle regulatory protein, also known as CIP1.The p21 protein inhibits cell cycle progression at both the G1 and G2 checkpoints. The expression of p21 is inducible by a wide range of stress stimuli.This antibody detects a band of approximately 21kD in MCF-7 cell lysates following UV radiation.

Characteristics: Purified IgG

Purification: Purified

Immunogen: Human p21 protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-p21 antibody (ABIN2475991)

Kotala, Uldrijan, Horky, Trbusek, Strnad, Vojtesek: "Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases." in: Cellular and molecular life sciences : CMLS, Vol. 58, Issue 9, pp. 1333-9, (2001) (PubMed).

Kolár, Murray, Scott, Harrison, Vojt?sek, Dusek: "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer." in: Molecular pathology : MP, Vol. 53, Issue 1, pp. 15-8, (2000) (PubMed).

Target Details for p21

Target: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Alternative Name: p21/WAF1

Gene ID: 1026

UniProt: P38936

Pathways: p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy