Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Specificity
The antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine 743/668.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Amyloid beta A4 (phospho Thr743/668) antibody was raised against a peptide sequence around phosphorylation site of threonine 743 /668 (A-V-T (p)-P-E) derived from Human Amyloid beta A4.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.