Bloom Syndrome (pThr99) antibody
Reactivity: Human
IHC, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Bloom Syndrome
-
Binding Specificity
- pThr99
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- Un-conjugated
-
Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- The antibody detects endogenous levels of Bloom Syndrome Protein only when phosphorylated at threonine 99.
- Purification
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- Bloom Syndrome (phospho Thr99) antibody was raised against a peptide sequence around phosphorylation site of threonine 99 (Q-E-T (p)-Q-R) derived from Human Bloom Syndrome.
- Isotype
- IgG
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anti-Bloom Syndrome (AA 65-114), (pThr99) antibody
Reactivity: Human IHC, ELISA, WB, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store antibody at -20°C for up to one year.
-
- Target
- Bloom Syndrome
- Background
- Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).
- Molecular Weight
- 159 kDa
- Gene ID
- 641
- NCBI Accession
- NP_000048
- UniProt
- P54132
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