PTK2B antibody (pTyr579)
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- Target See all PTK2B Antibodies
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
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Binding Specificity
- pTyr579
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PTK2B antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- The antibody detects endogenous levels of PYK2 only when phosphorylated at tyrosine 579.
- Purification
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Immunogen
- PYK2 (phospho Tyr579) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 579 (E-D-Y (p)-Y-K) derived from Human PYK2.
- Isotype
- IgG
- Top Product
- Discover our top product PTK2B Primary Antibody
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- Application Notes
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store antibody at -20°C for up to one year.
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- Target
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- Alternative Name
- PYK2 (PTK2B Products)
- Synonyms
- CADTK antibody, CAKB antibody, FADK2 antibody, FAK2 antibody, PKB antibody, PTK antibody, PYK2 antibody, RAFTK antibody, CAKbeta antibody, E430023O05Rik antibody, Raftk antibody, Pyk2 antibody, fak1b antibody, ptk2.2 antibody, ptk2b antibody, si:ch1073-355e8.1 antibody, protein tyrosine kinase 2 beta antibody, PTK2 protein tyrosine kinase 2 beta antibody, protein tyrosine kinase 2aa antibody, PTK2B antibody, Ptk2b antibody, ptk2aa antibody
- Background
- Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
- Molecular Weight
- 116 kDa
- Gene ID
- 2185
- NCBI Accession
- NP_004094
- UniProt
- Q14289
- Pathways
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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