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SREBF1 antibody (pSer439)
SREBF1
Reactivity: Human, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SREBF1 Antibody
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Target
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SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Binding Specificity
All epitopes for SREBF1 antibodies
pSer439
Reactivity
All reactivities for SREBF1 antibodies
Human, Rat
Host
All hosts for SREBF1 antibodies
Rabbit
Clonality
All clonalities for SREBF1 antibodies
Polyclonal
Conjugate
All conjugates for SREBF1 antibodies
This SREBF1 antibody is un-conjugated
Application
All applications for SREBF1 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p)-P-L) derived from Human SREBP-1 .
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for SREBF1
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Target
SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Alternative Name
SREBP-1 (SREBF1 Products )
Synonyms
SREBP-1c antibody, SREBP1 antibody, bHLHd1 antibody, ADD-1 antibody, ADD1 antibody, D630008H06 antibody, SREBP-1 antibody, SREBP-1a antibody, SREBP1c antibody, Srebp1 antibody, SCREBP1 antibody, SREBP-1C antibody, SREBF1 antibody, srebp1 antibody, sterol regulatory element binding transcription factor 1 antibody, sterol regulatory element binding transcription factor 1 L homeolog antibody, sterol regulatory element binding protein-1 antibody, Sterol regulatory element Binding Protein antibody, SREBF1 antibody, Srebf1 antibody, srebf1.L antibody, SREBP-1 antibody, srebf1 antibody, sbp-1 antibody
Background
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Molecular Weight
122 kDa
Gene ID
6720
NCBI Accession
NP_001005291
UniProt
P36956
Pathways
AMPK Signaling , Caspase Cascade in Apoptosis , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
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