The antibody detects endogenous levels of SYK only when phosphorylated at tyrosine 352.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
SYK (phospho Tyr352) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 352 (S-P-Y (p)-A-D) derived from Human SYK.
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion