This Topoisomerase II alpha antibody is un-conjugated
Application
Western Blotting (WB)
Specificity
The antibody detects endogenous levels of TOP2A only when phosphorylated at threonine 1343.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
TOP2A (phospho Thr1343) antibody was raised against a peptide sequence around phosphorylation site of threonine1343 (E-K-T (p)-D-D) derived from Human TOP2A.
TOP2 antibody, TP2A antibody, TOP2A antibody, Top-2 antibody, TOP-2 antibody, F12B17.110 antibody, F12B17_110 antibody, thimet metalloendopeptidase 2 antibody, fc08c07 antibody, wu:fc08c07 antibody, DNA topoisomerase II alpha antibody, DNA topoisomerase II, alpha isozyme antibody, topoisomerase (DNA) II alpha antibody, Zincin-like metalloproteases family protein antibody, TOP2A antibody, Bm1_08705 antibody, Top2a antibody, AT5G10540 antibody, top2a antibody
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event.