SYK antibody (AA 5-360)

Catalog No. ABIN2573229

Product Details anti-SYK Antibody

Target: SYK (Spleen tyrosine Kinase (SYK))

Binding Specificity: AA 5-360

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SYK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Brand: IHC-plus™

Specificity: Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.

Purification: Protein A purified

Immunogen: Recombinant fragment corresponding to amino acids 5 - 360 of human Syk.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Approved: IHC, IHC-P (10 μg/mL), IP, WB

Usage: Western Blot: Detects a band of approximately 72kD in Ramos and RBL cell lysates.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Alternative Name: SYK (SYK Products)

Synonyms: p72-Syk antibody, Sykb antibody, p72syk antibody, spleen associated tyrosine kinase antibody, spleen tyrosine kinase antibody, syk antibody, SYK antibody, Syk antibody

Background: Name/Gene ID: SYK
Subfamily: Syk/ZAP70
Family: Protein Kinase

Synonyms: SYK, p72syk, Spleen tyrosine kinase, Syk protein-tyrosine kinase, Tyrosine-protein kinase SYK, p72-Syk

Gene ID: 6850

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling