CACNA1G antibody

Catalog No. ABIN265033

Product Details anti-CACNA1G Antibody

Target: CACNA1G (Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1G antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to CACNA1G.

Purification: Purified

Immunogen: Synthetic peptide derived from the rat alpha1G calcium channel conjugated to KLH.

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for CACNA1G

Target: CACNA1G (Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G))

Alternative Name: CACNA1G (CACNA1G Products)

Synonyms: CACNA1G antibody, cav3.1 antibody, ca(v)3.1 antibody, Ca(V)T.1 antibody, Cav3.1 antibody, NBR13 antibody, Cav3.1d antibody, [a]1G antibody, a1G antibody, alpha-1G antibody, mKIAA1123 antibody, Ca(v)3.1 antibody, calcium voltage-gated channel subunit alpha1 G antibody, calcium channel, voltage-dependent, T type, alpha 1G subunit antibody, calcium channel, voltage-dependent, T type, alpha 1G subunit L homeolog antibody, CACNA1G antibody, cacna1g antibody, cacna1g.L antibody, Cacna1g antibody

Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1g gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. alpha(1G) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway.Synonyms: Cav3.1, Cav3.1c, KIAA1123, NBR13, Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-gated calcium channel subunit alpha Cav3.1

Gene ID: 8913

NCBI Accession: NP_061496

UniProt: O43497