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ROBO1 antibody
ROBO1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ROBO1 Antibody
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Target
See all ROBO1 Antibodies
ROBO1
(Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
Reactivity
All reactivities for ROBO1 antibodies
Human
Host
All hosts for ROBO1 antibodies
Rabbit
Clonality
All clonalities for ROBO1 antibodies
Polyclonal
Conjugate
All conjugates for ROBO1 antibodies
This ROBO1 antibody is un-conjugated
Application
All applications for ROBO1 antibodies
Western Blotting (WB)
Specificity
This antibody detects Roundabout homolog 1 / ROBO1, widely expressed, with exception of kidney.
Purification
Purified
Immunogen
Synthetic peptide derived from human ROBO1 protein
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Alternatives
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Application Details
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Application Notes
Western Blot (1-5 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate buffered saline with 0.08 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Target Details for ROBO1
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Target
ROBO1
(Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
Alternative Name
ROBO1 (ROBO1 Products )
Synonyms
DUTT1 antibody, SAX3 antibody, AW494633 antibody, AW742721 antibody, Gm310 antibody, ROBO1 antibody, dutt1 antibody, roundabout antibody, sax3 antibody, MGC122264 antibody, roundabout-1 antibody, roundabout guidance receptor 1 antibody, roundabout, axon guidance receptor, homolog 1 (Drosophila) antibody, roundabout guidance receptor 1 L homeolog antibody, ROBO1 antibody, Robo1 antibody, robo1 antibody, robo1.L antibody
Background
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.Synonyms: DUTT1, Deleted in U Twenty Twenty, ROBO-1, Roundabout homolog 1
Gene ID
6091
NCBI Accession
NP_002932
UniProt
Q9Y6N7
Pathways
Positive Regulation of Endopeptidase Activity
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