IL1R1 antibody (Biotin)

Catalog No. ABIN2660926

The Hamster Monoclonal anti-IL1R1 antibody is suitable to detect IL1R1 in samples from Mouse. It has been validated for ScA.

Quick Overview for IL1R1 antibody (Biotin) (ABIN2660926)

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This IL1R1 antibody is conjugated to Biotin

Application: Screening Assay (ScA)

Clone: JAMA-147

Product Details anti-IL1R1 Antibody (Biotin)

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL1R1

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Alternative Name: CD121a

Background: CD121a is an 80 kD IL-1 receptor type I. It is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.

Pathways: NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints