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LAG3 antibody (Biotin)

LAG3 Reactivity: Mouse IHC, FACS, IF Host: Rat Monoclonal C9B7W Biotin
Catalog No. ABIN2660995
  • Target See all LAG3 Antibodies
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    Reactivity
    • 87
    • 33
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Mouse
    Host
    • 52
    • 34
    • 7
    • 4
    Rat
    Clonality
    • 53
    • 41
    • 1
    Monoclonal
    Conjugate
    • 52
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAG3 antibody is conjugated to Biotin
    Application
    • 68
    • 36
    • 30
    • 29
    • 25
    • 21
    • 15
    • 13
    • 13
    • 10
    • 9
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
    Clone
    C9B7W
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product LAG3 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    Alternative Name
    CD223 (LAG3 Products)
    Synonyms
    CD223 antibody, LAG-3 antibody, Ly66 antibody, lymphocyte activating 3 antibody, lymphocyte-activation gene 3 antibody, LAG3 antibody, Lag3 antibody
    Background
    CD223, also known as LAG-3, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. It is the gene product of lymphocyte activation gene-3 (Lag3) with structural similarity to CD4. CD223 is expressed on activated T cells and NK cells, as well as T regulatory cells. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. In association with the CD3 complex, CD223 has been shown as a negative regulatory molecule to inhibit TCR-mediated signaling and regulate homeostatic T cell expansion. In contrast to inhibition, CD223 has an activation function to promote immune responses by inducing MHC class II signaling in antigen presenting cells.
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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