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SEMA4D/CD100 antibody (FITC)
SEMA4D
Reactivity: Human
FACS, ICFC
Host: Mouse
Monoclonal
A8
FITC
Product Details anti-SEMA4D/CD100 Antibody (FITC)
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Target
See all SEMA4D/CD100 (SEMA4D) Antibodies
SEMA4D/CD100 (SEMA4D)
(Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
Reactivity
All reactivities for SEMA4D/CD100 antibodies
Human
Host
All hosts for SEMA4D/CD100 antibodies
Mouse
Clonality
All clonalities for SEMA4D/CD100 antibodies
Monoclonal
Conjugate
All conjugates for SEMA4D/CD100 antibodies
This SEMA4D/CD100 antibody is conjugated to FITC
Application
All applications for SEMA4D/CD100 antibodies
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
Cross-Reactivity
Cynomolgus
Purification
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone
A8
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for SEMA4D/CD100
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Target
SEMA4D/CD100 (SEMA4D)
(Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
Alternative Name
CD100 (SEMA4D Products )
Synonyms
C9orf164 antibody, CD100 antibody, M-sema-G antibody, SEMAJ antibody, coll-4 antibody, Semacl2 antibody, Semaj antibody, Semcl2 antibody, COLL-4 antibody, semaphorin 4D antibody, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D antibody, Sema4d antibody, SEMA4D antibody
Background
CD100, a 150 kD homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
Pathways
Regulation of Cell Size
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