KLRA1 antibody (PE)

Catalog No. ABIN2663821

Product Details anti-KLRA1 Antibody (PE)

Target: KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This KLRA1 antibody is conjugated to PE

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: YE1-48-10-6

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for KLRA1

Target: KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))

Alternative Name: Ly-49A (KLRA1 Products)

Synonyms: Klra2 antibody, Ly49i8 antibody, A1 antibody, Klra22 antibody, Ly49a antibody, Ly49o<129> antibody, Ly49v antibody, LY49 antibody, KLRA1 antibody, Ly49 antibody, killer cell lectin-like receptor, subfamily A, member 1 antibody, killer cell lectin-like receptor subfamily A, member 1 antibody, Klra1 antibody, KLRA1 antibody, LY49 antibody

Background: Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.