DDR1 antibody

Catalog No. ABIN2664284

The Mouse Monoclonal anti-DDR1 antibody (Clone 51D6) (ABIN2664284) specifically detects DDR1 in FACS. The antibody is reactive with Human samples.

Quick Overview for DDR1 antibody (ABIN2664284)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 51D6

Product Details anti-DDR1 Antibody

Characteristics: The 51D6 monclonal antibody recognizes human CD167a also known as discoidin domain receptor, DDR1, neuroepithelial tyrosine kinase, epithelial-specific receptor kinase, tyrosine kinase receptor E (trkE), cell adhesion kinase (CAK), PTK3, and RTK6. CD167a is a membrane type II receptor kinase, containing a factor VIII-like domain. At least five isoforms are generated through alternative splicing of the kinase domain of human DDR1 gene. These isoforms are named with suffixes a to e. CD167a is expressed on epithelial cells, keratinocytes, leukocytes, monocytes and has been reported to be overexpressed in some breast carcinomas. CD167a expression can be upregulated by p53. CD167a has been reported to interact with a variety of proteins including collagen type II alpha 1, collagen type III alpha 1, collagen type V alpha 2, collagen type XI alpha 1, phospholipase gamma 1, SHC, and the lipid-anchored docking protein FRS2. CD167a can be phosphorylated on Y513. Animal studies suggest that CD167a is involved in arterial wound healing. The 51D6 antibody has been shown to be useful for flow cytometric detection of human CD167a as well as immunoprecipitation.

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG3 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: CD167a

Pathways: RTK Signaling, Smooth Muscle Cell Migration