IFNB1 antibody

Catalog No. ABIN2665064

The Hamster Monoclonal anti-IFNB1 antibody (Clone MIB-5E9-1) (ABIN2665064) specifically detects IFNB1 in WB, IHC and IP. The antibody is reactive with Mouse samples.

Quick Overview for IFNB1 antibody (ABIN2665064)

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This IFNB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: MIB-5E9-1

Product Details anti-IFNB1 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IFNB1

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Alternative Name: IFN-beta

Background: Interferon-β is a member of the type I interferon class. Type I IFNs are involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once secreted by virus-infected or activated cells, they bind to the IFNα/β receptor (IFNAR), which is found on almost all cell types, and, via the JAK-STAT pathway, induce the expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral activities, both general and specific against particular viruses. Type I IFNs also regulate cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects. As such, they are also clinically relevant, both as therapeutics and as targets of inhibition for the treatment of various autoimmune diseases and cancer. Mouse IFN-β is a ~20 kD monomeric glycoprotein. It has 50 % amino acid sequence homology with mouse IFN-α, its closest related protein, and 62 % homology with human IFN-β. IFN-β is currently the therapeutic of choice for treating multiple sclerosis.

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome